DPY30 Regulates Pathways in Cellular Senescenece through ID Protein Expression

Thanks you very much for submitting your study on DPY30 in regulating cellular senescence for consideration to The EMBO Journal editorial office. Once more, apologies for the slight delay in providing comments, still caused by the recent holiday season. You will easily recognize that the referees are in principle supportive of the data. They do provide however very constructive comments to broaden the scope by assessing more epigenetic marks (point 1 ref#1). This very relevant point would also strengthen the proposed mechanism that ref#3 judges as currently quite weak. It would further be essential to address potentially conflicting results re SASP-factor expression (point #2, ref#1), expand the set of senescence marker (point 4, ref#1) and indeed aim for some physiological significance of this pathway (point 3, ref#1), preferably in a way/the system you eluted to in our previous correspondence?!